ABSTRACT

Kelly M, Jones ET, Shapshak D. Rapid Progression of Cutaneous Large B-Cell Lymphoma During Hyperbaric Oxygen Therapy: A Case Report. Undersea Hyperb Med. 2025 Third Quarter; 52(3):357- 360.

We present a case of a patient with a history of chronic lymphocytic leukemia (CLL) and cutaneous B-cell lymphoma of the right leg. She had previously received radiation treatment to the affected area and subsequently developed radiation fibrosis with two non-healing ulcerations at the previous tumor sites. A biopsy revealed spongiotic and sparse superficial perivascular dermatitis. Due to poor wound healing, adjunctive hyperbaric oxygen (HBO2) therapy was initiated. However, shortly after beginning HBO2 treatments, the wounds worsened. Repeat biopsies were performed, and the new areas were consistent with cutaneous large B-cell lymphoma. Consequently, HBO2 therapy was discontinued, and aggressive chemotherapy/immunotherapy was initiated. We recommend that patients with a history of cutaneous B-cell lymphoma be closely monitored for signs of tumor recurrence or disease worsening if they are to undergo adjunctive hyperbaric oxygen therapy.

Keywords: cancer; cutaneous large B-cell lymphoma; hyperbaric oxygen therapy; wounds