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We report the case of a 49-year-old patient who presented with ischemia-reperfusion injury (IRI) of her right hand following a dialysis access-steal syndrome treated by arteriovenous fistula ligation. Subsequently, she was treated with three daily 90-minute hyperbaric oxygen treatments and had remarkable improvement in her symptoms of pain, numbness and swelling. The patient demonstrated regain of function at three-weeks post-treatment, with full recovery of function at six months post-treatment. The non-invasive and relatively safe nature of hyperbaric oxygen therapy supports its use as a potential treatment for IRI.